About how much fentanyl has been seized
phenytoin will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on into a minimize in fentanyl plasma concentrations, lack of efficacy or, probably, growth of a withdrawal syndrome in the affected individual